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Description

In addition to KRAS G13C , we also investigated the reactivities towards KRAS G12C 1169 (Cys-light) and KRAS wt 1169 , where no to very low modification was observed, indicating good overall selectivity towards Cys13 (Figure S1)

To determine whether combined inhibition of GGCT and xCT results in synergistic effects, we treated cells with pro-GA and erastin at a fixed ratio for 3 days